| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A Single Session of tDCS Stimulation Can Modulate an EEG Microstate Associated With Anxiety in Patients With Depression. |
| 掲載誌名 | 正式名：Brain and behavior 略 称：Brain Behav ISSNコード：21623279 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 15(5),pp.e70580 |
| 著者・共著者 | Keiichiro Nishida, Shota Minami, Tomonari Yamane, Satsuki Ueda, Banri Tsukuda, Shunichiro Ikeda, Daisuke Haruna, Masafumi Yoshimura, Tetsufumi Kanazawa, Thomas Koenig |
| 発行年月 | 2025/05 |
| 概要 | PURPOSE:Microstate analysis involves examining the temporal dynamics of electroencephalogram (EEG) signals and serves as a crucial method for exploring the neural basis of psychiatric disorders. This study investigates the effects of transcranial direct current stimulation (tDCS) on specific microstate parameter maps-D and C in patients with depression, specifically targeting the dorsomedial prefrontal cortex (DMPFC) and left dorsolateral prefrontal cortex (DLPFC).METHODS:We conducted an open-label, between-subject, crossover trial involving 19 patients clinically diagnosed with depression. A 1 mA electrical current was administered, with anodal stimulation specifically targeting the DMPFC or the left DLPFC. Microstate maps were derived from resting-state EEG recordings obtained prior to and following the application of tDCS. The EEG data were categorized into five distinct microstate classes for subsequent analysis.FINDINGS:The findings revealed a significant increase in the duration of microstate class D following stimulation in both groups, while microstate class C exhibited no notable changes. Additionally, a significant association was identified between the transition from microstate D to C and alterations in the State-Trait Anxiety Inventory-State (STAI-S) scores after left DLPFC stimulation.CONCLUSION:Microstate map D appears to be associated with psychiatric disorders and executive functions, whereas map C may relate to the salience network and mind-wandering. Our findings suggest that microstate maps D and C are responsive to tDCS stimuli, indicating their potential as objective tools for anxiety assessment. Employing transition-focused parameters in EEG microstate analysis may enhance the tracking of rapidly fluctuating emotional states, rather than relying solely on duration metrics. Furthermore, the integration of non-invasive brain stimulation techniques, such as tDCS, with EEG microstate analysis holds significant promise for elucidating the neural mechanisms involved in depression.TRIAL REGISTRATION:UMIN-CTR Clinical Trial: UMIN000015046. |
| DOI | 10.1002/brb3.70580 |
| PMID | 40384048 |