| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Treatment of thrombotic cardiovascular diseases in people with haemophilia: A Japanese consensus study. |
| 掲載誌名 | 正式名：Haemophilia : the official journal of the World Federation of Hemophilia 略 称：Haemophilia ISSNコード：13652516/13518216 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 30(4),pp.933-942 |
| 著者・共著者 | Azusa Nagao, Yushi Chikasawa, Yukio Hiroi, Masahiro Ieko |
| 発行年月 | 2024/07 |
| 概要 | INTRODUCTION:Cardiovascular diseases (CVD) that require long-term anticoagulant and antiplatelet therapy presents a problem in people with haemophilia (PWH) who receive factor replacement therapy to reduce bleeding risk. Currently, there are no Japanese guidelines for the management of PWH with CVD.AIM:To develop expert guidance on managing CVD in PWH in Japan.METHODS:A steering committee of four experts (two haemophilia specialists, one thrombosis specialist, one cardiologist) identified 44 statements related to five key themes. An online questionnaire was produced comprising a mix of 4-point Likert scale and multiple-choice questions that was sent to specialists in the management of PWH with CVD in Japan. Consensus was defined as high or very high if a respective ≥75% or ≥90% of respondents agreed with a statement.RESULTS:Of 16 potential respondents, responses were received from 15 specialists. Of the Likert scale questions, 71% (29/41) achieved ≥90% agreement (very strong agreement), 17% (7/41) achieved 75%-89% agreement (strong agreement) and 15% (6/41) did not achieve consensus agreement. The three multiple-choice questions failed to identify a strong preference. Agreement on specific target trough clotting factor levels for managing certain clinical situations, such as when in the presence of non-valvular atrial fibrillation or myocardial infarction, was also achieved.CONCLUSION:The results of this consensus study provide a framework for cardiologists and haematologists to manage PWH who are at risk of, or who have, CVD. Implementation of the recommendations provided herein may improve outcomes for PWH with CVD. |
| DOI | 10.1111/hae.15039 |
| PMID | 38783547 |