論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Development and Validation of the SDLD-Score: a Simplified Tool to Predict Successful Endoscopic Papillectomy in Ampullary Lesions.
掲載誌名	正式名：Gastrointestinal endoscopy 略　 称：Gastrointest Endosc ISSNコード：10976779/00165107
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Kien Vu Trung, Einas Abou-Ali, Aiste Gulla, Kevin Soares, Fabrice Caillol, Woo H Paik, Bertrand Napoleon, Asif Halimi, Viliam Masaryk, Marco J Bruno, Enrique Pérez-Cuadrado-Robles, Louisa Bolm, Steffen Seyfried, Maria C Petrone, Bengisu Yilmaz, Charles Vollmer, Arthur Berger, Laura Maggino, Peter Schemmer, Dörte Wichmann, Elias Karam, Ana Dugic, Lumir Kunovsky, Sara Regner, Sebastien Gaujoux, Marcus Hollenbach, ; Study group:Sohei Satoi 80
発行年月	2025/05
概要	BACKGROUND AND STUDY AIMS:Endoscopic papillectomy (EP) is the standard treatment for non-invasive ampullary lesions (AL), while advanced cases require surgery. Managing AL is challenging and may lead to over- or undertreatment. We developed a score to identify the best candidates for endoscopic or surgical treatment.PATIENTS AND METHODS:We analyzed 447 patients who underwent EP. The cohort was randomly split into a training (n=325) and validation set (n=122). Logistic regression identified predictors for incomplete resection (R1), which were incorporated into a four-item score. Performance was assessed using AUROC.RESULTS:Independent predictors for R1 included size≥30mm(S), high-grade dysplasia/invasive cancer(D), laterally-spreading-lesion(L), and bile/pancreatic duct dilation(D). AL with 0-1 points had the highest R0 rates (training: 86.0%; validation: 88.5%), while ≥2 points significantly increased R1 rates (training: 52.0%; validation: 57.7%; p<0.001). AUROC was 0.792 (training) and 0.708 (validation).CONCLUSION:The SDLD score predicts incomplete resection in EP and aids treatment decisions.
DOI	10.1016/j.gie.2025.03.1333
PMID	40449630