論文種別	総説
言語種別	英語
査読の有無	その他(不明)
表題	'Can we cure IgG4-related diseases?'.
掲載誌名	正式名：Current opinion in immunology 略　 称：Curr Opin Immunol ISSNコード：18790372/09527915
掲載区分	国外
巻・号・頁	95,pp.102564
著者・共著者	Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida
発行年月	2025/08
概要	IgG4-related disease (IgG4-RD), recognized as a novel clinical entity, is a rare, chronic, immune-mediated systemic fibroinflammatory disorder of unknown origin with either synchronous or metachronous multi-organ involvement. Although the pathogenic mechanism remains unclear, possible multipathogenic factors such as genetic backgrounds, disease-specific or related antigens, and abnormal innate or adaptive immunity may be involved. Many immunocytes, including neutrophil extracellular trap, M2 macrophage, plasmablast, B cells, and T-cells (Th2-CD4+T, follicular helper T cells, and CD4+SLAMF7+cytotoxic T cells) play important roles in the pathogenesis. Conventional therapies with glucocorticoid or rituximab in combination with/without immunomodulators are recommended in all symptomatic patients with active IgG4-RD. Because of a few of randomized clinical trials, the comprehensive management for IgG4-RD has not been established yet. Targeted treatment approaches against the plasmablast to B cell lineage and the CD4+SLAMF7+cytotoxic T cell seem to be promising for the future-directed treatment.
DOI	10.1016/j.coi.2025.102564
PMID	40398200