論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Plaque rupture and calcified nodules: major contributors to out-of-hospital cardiac arrest in acute myocardial infarction.
掲載誌名	正式名：Cardiovascular intervention and therapeutics 略　 称：Cardiovasc Interv Ther ISSNコード：18684297/18684297
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Takato Hirose, Kenichi Fujii, Kenta Hashimoto, Kazunori Bando, Shun Morishita, Masanao Taniichi, Keita Horitani, Ichiro Shiojima
発行年月	2025/06
概要	Since patients with cardiac arrest associated with acute myocardial infarction (MI) may not be successfully resuscitated, the underlying mechanisms of acute MI leading to out-of-hospital cardiac arrest (OHCA) have not been elucidated. This study evaluated whether there are differences in the plaque characteristics of infarct-related lesions between acute MI patients with OHCA and those without OHCA. This study analyzed 604 consecutive patients with a diagnosis of acute MI who underwent intravascular ultrasound (IVUS) evaluation of the infarct-related lesion before coronary intervention. All study patients were divided into two groups based on whether they presented with OHCA. The underlying mechanisms of acute MI were classified into four categories according to pre-interventional angiographic and IVUS images: plaque rupture, plaque erosion, calcified nodule, and embolization. Of the 604 patients diagnosed with acute MI, 69 (11%) suffered from OHCA. The OHCA group had a higher frequency of plaque rupture and calcified nodules than the non-OHCA group. Multivariate logistic regression analysis showed that an infarct-related lesion in the left main artery, the underlying plaque morphology of a calcified nodule, and plaque rupture were significantly associated with OHCA. In patients with acute MI, plaque morphology of infarct-related lesions with plaque rupture or a calcified nodule has a higher risk of leading to OHCA than other morphological types.
DOI	10.1007/s12928-025-01146-1
PMID	40478392