論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Pulmonary artery and aortic enlargement predict postoperative survival outcomes in lung cancer.
掲載誌名	正式名：Interdisciplinary cardiovascular and thoracic surgery 略　 称：Interdiscip Cardiovasc Thorac Surg ISSNコード：2753670X/2753670X
掲載区分	国外
巻・号・頁	40(7),pp.ivaf142
著者・共著者	Haruaki Hino, Osamu Honda, Kosuke Kashiwabara, Natsumi Maru, Takahiro Utsumi, Kento Fukumoto, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Tomohiro Murakawa
発行年月	2025/07
概要	OBJECTIVES:The pulmonary artery/aorta ratio can predict postoperative outcomes in patients with lung cancer; however, few studies have investigated the effects of individual changes in the pulmonary artery and aortic diameters. This study aimed to analyze the impact of pulmonary artery and aortic enlargement on outcomes following surgery for lung cancer.METHODS:We retrospectively analyzed data from 1,482 patients with non-small cell lung cancer who underwent radical surgery at our institution between 2006 and 2022. The maximum diameters of the pulmonary artery and ascending aorta were measured using preoperative computed tomography, and patients were divided according to cutoff values set for the receiver operating characteristic curve. All patients were then stratified into three groups: non-enlarged pulmonary artery and aorta ("normal" group, n = 244), enlargement of either the pulmonary artery or aorta ("either enlargement" group, n = 689), and enlargement of both the pulmonary artery and aorta ("both enlargement" group, n = 549). The preoperative clinical characteristics and postoperative outcomes were analyzed in these three groups.RESULTS:Five-year overall survival rates in the "normal," "either enlargement," and "both enlargement" groups were 80.2%, 77.3%, and 71.0% (P = 0.002), respectively. Enlargement of both vessels was an independent negative prognostic factor for both overall survival (hazard ratio, 1.56; P = 0.04) and cancer-specific death (hazard ratio, 1.83; P = 0.03). However, this association was not significant for non-cancer-specific deaths (hazard ratio, 1.39; P = 0.35).CONCLUSIONS:Measurement of the pulmonary artery and aortic diameters might be a useful predictor of postoperative survival in patients with lung cancer.
DOI	10.1093/icvts/ivaf142
PMID	40577801