| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Patients With Pancreatic Cancer With Synchronous Liver Oligometastasis Show a Significant Long-Term Survival Benefit From Resection Under Specific Conditions: A Multicenter National Cohort Study. |
| 掲載誌名 | 正式名：Journal of hepato-biliary-pancreatic sciences 略 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 32(8),pp.611-619 |
| 著者・共著者 | Kohei Nakata, Yoshihiro Miyasaka, Takeaki Ishizawa, Masayuki Ohtsuka, Masamichi Mizuma, Sohei Satoi, Masaaki Hidaka, Shuji Suzuki, Hiroshi Kurahara, Chie Kitami, Satoshi Hirano, Dongha Lee, Saiho Ko, Munenori Tahara, Isaku Yoshioka, Kenjiro Date, Kazuyuki Nagai, Goro Honda, Shugo Mizuno, Kenichi Hakamada, Yasuro Futagawa, Shigeru Marubashi, Hiroshi Yoshida, Akihiko Horiguchi, Yasuo Hosouchi, Masafumi Imamura, Naoto Gotohda, Hiroaki Nagano, Masaji Tani, Takeshi Sudo, Teijiro Hirashita, Junichi Arita, Katsutoshi Murase, Ken Fukumitsu, Toshiki Rikiyama, Teruyuki Usuba, Toshiya Abe, Masafumi Nakamura, Itaru Endo |
| 発行年月 | 2025/08 |
| 概要 | BACKGROUND:In this study, we investigated the criteria that predict the long-term survival benefits after surgical resection in patients with pancreatic cancer accompanied by liver oligometastasis.METHODS:In total, 60 patients from 34 high-volume Japanese centers who underwent surgical resection for liver oligometastasis between 2005 and 2020 were included. Univariate and multivariate methods of survival analyses were performed. All patients were followed up for at least 36 months.RESULTS:Overall survival (OS) was significantly longer in the preoperative chemotherapy group than in the up-front surgery group (37.4 vs. 20.4 months, p = 0.001). In the operation with preoperative chemotherapy group, a complete response was observed in eight patients (28.6%). The 1-, 3-, and 5-year OS rates were 92.9%, 50.0%, and 35.7%, respectively. The multivariate analysis showed that low CA19-9 (< 100 U/mL; HR: 0.25; 95% CI: 0.06-0.96; p = 0.043), low CEA (< 5 U/mL; HR: 0.14; 95% CI: 0.04-0.48; p = 0.002), and resectable (R) or borderline resectable pancreatic cancer invading the portal vein (BR-PV) status (HR: 0.19; 95% CI: 0.07-0.51; p < 0.001) were positive prognostic factors. The median OS of the patients who met all three criteria was 106.6 months.CONCLUSION:Preoperative chemotherapy is essential for the treatment of liver oligometastases. Despite the high recurrence rates, patients who met the specific criteria have a favorable prognosis with liver resection. |
| DOI | 10.1002/jhbp.12181 |
| PMID | 40653657 |