| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Dermatologically Tested Apple-Derived Extracellular Vesicles: Safety, Anti-Aging, and Soothing Benefits for Skin Health. |
| 掲載誌名 | 正式名：Journal of cosmetic dermatology 略 称：J Cosmet Dermatol ISSNコード：14732165/14732130 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 24(7),pp.e70254 |
| 著者・共著者 | Lucia Sileo, Maria Pia Cavaleri, Luca Lovatti, Giuseppe Pezzotti, Letizia Ferroni, Barbara Zavan |
| 発行年月 | 2025/07 |
| 概要 | UNLABELLED:Extracellular vesicles (EVs) derived from plant sources, particularly apple-derived vesicles (ADVs), have gained interest for their biocompatibility and bioactive properties in cosmetic, dermatological, and regenerative medicine applications. This study aimed to evaluate the safety and efficacy of a 2% ADV-based formulation, assessing its potential for topical use through a series of standardized in vitro tests.MATERIALS AND METHODS:The ADV-based formulation was subjected to genotoxicity (Ames test), corneal toxicity, skin irritation, corrosion, and sensitization assays, following OECD guidelines. Additionally, its anti-inflammatory and anti-aging effects were assessed through skin redness reduction and wrinkle parameter analysis over 60 days.RESULTS:ADVs exhibited no genotoxic, cytotoxic, corrosive, or sensitizing effects, confirming their safety profile. The formulation significantly reduced skin redness (p < 0.05) and improved wrinkle length, volume, and roughness over time.CONCLUSION:These findings establish ADVs as safe and effective bioactive ingredients, supporting their potential integration into cosmetic and regenerative applications for skin health and anti-aging treatments. |
| DOI | 10.1111/jocd.70254 |
| PMID | 40686092 |