| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Dual energy X-ray absorptiometry-measured fat mass and lean mass indices and cardiometabolic diseases in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. |
| 掲載誌名 | 正式名：Environmental health and preventive medicine 略 称：Environ Health Prev Med ISSNコード：13474715/1342078X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 30,pp.59 |
| 著者・共著者 | Katsuyasu Kouda, Yuki Fujita, Yuki Murakami, Kumiko Ohara, Takahiro Tachiki, Junko Tamaki, Jong-Seong Moon, Etsuko Kajita, Akemi Nitta, Nami Imai, Kazuhiro Uenishi, Masayuki Iki |
| 発行年月 | 2025 |
| 概要 | BACKGROUND:High visceral fat mass (FM) is associated with a high risk of cardiometabolic morbidity. Meanwhile, loss of skeletal muscle (lean mass, LM) has been suggested to contribute to metabolic diseases.METHODS:We investigated associations between cardiometabolic diseases and dual energy X-ray absorptiometry (DXA)-measured body composition indices, including the FM index (FM/height2), percent body fat, trunk-to-appendicular fat ratio (TAR), trunk-to-leg fat ratio (TLR), LM index (LM/height2) and FM-to-LM ratio in 595 community-dwelling elderly Japanese men (mean age, 74 years; standard deviation, 6; range, 65 to 94). Hypertension was identified as high blood pressure and/or the use of antihypertensive drugs. Diabetes was identified as high hemoglobin A1c and/or the use of antidiabetic drugs. The ability of DXA-based indices to discriminate between the presence and absence of cardiometabolic diseases was evaluated using area under the curve (AUC) calculated by receiver operating characteristic curve analysis.RESULTS:Body mass index, FM index, percent body fat, TAR, TLR and FM-to-LM ratio were significantly associated with hypertension (P < 0.05). TAR and TLR, but not body mass index, FM index, percent body fat, LM index and FM-to-LM ratio, showed significant positive associations with diabetes. The AUC for the LM index was significantly lower than those for the FM index, percent body fat and FM-to-LM ratio. No associations were observed between the LM index and hypertension, dyslipidemia and diabetes.CONCLUSION:The association between cardiometabolic function and LM, which includes skeletal muscle, may not be as pronounced or stronger than associations between cardiometabolic function and FM. Further detailed studies are needed to clarify how skeletal muscle contributes to cardiometabolic disease. |
| DOI | 10.1265/ehpm.25-00133 |
| PMID | 40707205 |