| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Clinical Benefits of Reprogramming Chronic Subthalamic Stimulation in Parkinson's Disease. |
| 掲載誌名 | 正式名：Movement disorders clinical practice 略 称：Mov Disord Clin Pract ISSNコード：23301619/23301619 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Jumpei Sugiyama, Yuwa Oka, Shohei Imanaka, Kazuma Ota, Atsushi Tsujimura, Masahiro Sawada, Yosuke Taruno, Yoshito Sugita, Namiko Nishida, Takayoshi Ishimori, Makio Takahashi, Satoshi Kaneko, Hiroki Toda |
| 発行年月 | 2025/08 |
| 概要 | BACKGROUND:Reprogramming of chronic deep brain stimulation (DBS) in Parkinson's disease is often underutilized despite potential clinical benefit.OBJECTIVE:The aim was to assess the impact of systematic reprogramming in patients with long-term subthalamic nucleus (STN) DBS.METHODS:Ten patients with long-term STN-DBS underwent systematic reprogramming due to recurrence of motor symptoms or increased medication needs. Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III scores (medication off/DBS ON) and levodopa equivalent daily dose (LEDD) were compared across initial programming, pre-reprogramming, and post-reprogramming using repeated-measures analysis of variance (ANOVA).RESULTS:Reprogramming yielded a significant 24% improvement in MDS-UPDRS Part III scores (P = 0.02) without significant LEDD change. Imaging revealed that reprogramming commonly engaged dorsolateral or supra-STN regions by increasing amplitude or changing from bipolar to monopolar settings while maintaining contact pairs.CONCLUSIONS:Systematic reprogramming can improve long-term motor outcomes in STN-DBS. Imaging may assist in understanding and guiding effective reprogramming strategies. |
| DOI | 10.1002/mdc3.70281 |
| PMID | 40879710 |