| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Prevalence and Prognostic Implication of Sarcopenia Among Patients With Stage B Heart Failure: The PAPRIKA-HF Cohort Study. |
| 掲載誌名 | 正式名：Journal of the American Geriatrics Society 略 称：J Am Geriatr Soc ISSNコード：15325415/00028614 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Koichiro Matsumura, Shun Morishita, Junko Morimoto, Satoshi Kurose, Shohei Hakozaki, Eijiro Yagi, Masafumi Ueno, Yutaka Kimura, Gaku Nakazawa |
| 発行年月 | 2025/08 |
| 概要 | BACKGROUND:The long-term prognosis of patients with heart failure (HF) remains poor. Most patients with HF are older, and multiple factors involved in geriatric syndromes are associated with worse long-term prognosis. Sarcopenia is a major component of geriatric syndrome. Early diagnosis and therapeutic intervention for sarcopenia are clinically important in patients with HF; however, the prevalence and long-term prognostic impact of sarcopenia in patients with stage B HF remain unclear. This study aimed to determine the prevalence of sarcopenia in older patients with stage B HF and its impact on the long-term prognosis.METHODS:The PAPRIKA-HF study was a multicenter, prospective study that enrolled outpatients ≥ 65 years who were diagnosed with stage B HF. Sarcopenia was assessed based on the Asian Working Group for Sarcopenia 2019 diagnostic criteria. The primary endpoint was a composite endpoint (all-cause mortality, incident myocardial infarction, or hospitalization for heart failure) of > 2 years.RESULTS:Among 312 patients (mean age: 78.2 ± 6.5 years, 45% female), 17.7% (56 of 312 patients) had sarcopenia. The rate of the composite endpoint over 2 years was significantly higher in patients with sarcopenia than in those without (25.0% vs. 2.7%, log-rank test, p < 0.0001). Multivariate analysis using the Cox proportional hazards model showed that sarcopenia was an independent predictor of long-term prognosis (hazard ratio: 5.78, 95% confidence interval: 2.16-15.43, p < 0.001).CONCLUSIONS:Sarcopenia was associated with a worse long-term prognosis in older patients with stage B HF, highlighting the importance of early diagnosis of sarcopenia. |
| DOI | 10.1111/jgs.70046 |
| PMID | 40879204 |