| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Typical distribution of hypertensive cerebral microbleed: a matched case-control study using primary aldosteronism. |
| 掲載誌名 | 正式名：Hypertension research : official journal of the Japanese Society of Hypertension 略 称：Hypertens Res ISSNコード：13484214/09169636 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Shuhei Ikeda, Yusuke Yakushiji, Kotaro Iida, Tatsuya Doyama, Toshihiro Ide, Kohei Suzuyama, Haruki Koike |
| 発行年月 | 2025/08 |
| 概要 | The topographical distribution of non-strictly lobar cerebral microbleed (CMB) is considered as a neuroimaging marker of hypertensive arteriopathy, but pathological evidence remains insufficient. This case-control study assessed patients with primary aldosteronism (PA), a leading cause of secondary hypertension, to characterize the CMB distribution features of typical hypertensive arteriopathy. A PA group (n = 11) and an age-matched non-hypertensive control group (n = 22) were classified into subgroups based on the presence of any CMB or no CMB using paramagnetic-sensitive MRI. Patients with any CMB were further divided into strictly lobar CMB and non-strictly lobar CMB, defined as either strictly deep and/or infratentorial (D/I) CMB or "mixed" (i.e., CMB in both lobar and D/I regions). CMB prevalence was higher in the PA group (81.8% vs. 13.6%, p < 0.001), showing non-strictly lobar patterns in all cases. Total CMB count was also higher (median 3 vs. 0; p < 0.001). Adjusted odds ratios for any CMB and non-strictly lobar CMB were 80.24 and 89.89, respectively. These findings suggest that PA-related small vessel injury affects both deep and cortical/leptomeningeal arterioles, demonstrating a strong association between pure hypertensive small vessel disease and non-strictly lobar CMB distribution. |
| DOI | 10.1038/s41440-025-02352-3 |
| PMID | 40858750 |