論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone.
掲載誌名	正式名：Brain research bulletin 略　 称：Brain Res Bull ISSNコード：18732747/03619230
掲載区分	国外
巻・号・頁	231,pp.111535
著者・共著者	Megumi Taketo
発行年月	2025/09
概要	Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that mediate slow glutamatergic signal transduction and regulate cell excitability in the central nervous system. Group I mGluRs are coupled to Gq/11 proteins and mobilize intracellular Ca2+. Group II mGluRs are coupled to Gi/o proteins and inhibit adenylyl cyclase. Hippocampal Cajal-Retzius (CR) cells which regulate neural migration during pre- and post-natal development, express group I and group II mGluRs. Although interactions between GPCRs have been reported, studies on the interactions between GPCRs in native tissues remain insufficient. Previous studies have demonstrated that mGluR1, which belongs to group I mGluRs, mobilizes intracellular Ca2+ in CR cells, and this Ca2+ response is potentiated by activation of the Gi/o-coupling adenosine A1 receptor. In this study, the potentiation of intracellular Ca2+ mobilization through mGluR1 by the activation of group II mGluRs was demonstrated in hippocampal CR cells. Ca2+ imaging in hippocampal slices showed that activation of groupII mGluRs did not induce elevation of intracellular Ca2+ concentration, but potentiated mGluR1-induced Ca2+ responses. This potentiation was sensitive to a negative allosteric modulator of mGluR3, and several G-protein inhibitors. These results reveal cooperative modulation of intracellular Ca2+ mobilization by the two subtypes of mGluRs in hippocampal CR cells.
DOI	10.1016/j.brainresbull.2025.111535
PMID	40907773