論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Long-term trajectories of treatment-resistant schizophrenia following clozapine or electroconvulsive therapy: A retrospective observational study.
掲載誌名	正式名：Journal of psychiatric research 略　 称：J Psychiatr Res ISSNコード：18791379/00223956
掲載区分	国外
巻・号・頁	190,pp.531-539
著者・共著者	Hirotsugu Kawashima, Yoshiteru Takekita, Nobuatsu Aoki, Masaaki Hazama, Morio Aki, Kentaro Katsuragi, Takaaki Ando, Hiroto Sakai, Aran Tajika, Toshiya Murai, Taro Suwa
発行年月	2025/10
概要	BACKGROUND:Clozapine (CLZ) is the first-line treatment for treatment-resistant schizophrenia (TRS), but practical constraints often delay its implementation. Approximately 50 % of patients ultimately discontinue CLZ, primarily due to adverse events. Electroconvulsive therapy (ECT) has shown efficacy in TRS, though concerns remain regarding the durability of its effects. This study aimed to characterize the treatment effectiveness and clinical trajectories of patients with TRS following initial treatment with CLZ or ECT.METHODS:This study reviewed medical records of 116 patients with TRS initially treated with either CLZ (n = 63) or ECT (n = 53) at three tertiary care centers in Japan (2000-2020). The primary outcome was time to treatment failure, defined as readmission, ECT initiation, CLZ discontinuation/initiation, interruption of hospital attendance, or all-cause death. We traced patients' trajectories following initial treatment failure.RESULTS:Both groups showed similar treatment failure rates in the first year. Beyond this period, the CLZ group exhibited diminishing failure rates (median time: 2093 days), with discontinuation as the main reason. Among CLZ responders (42.9 %), 81.5 % maintained stability without readmission. The ECT group showed consistent failure occurrence (median: 589 days), with readmission as the primary reason. Despite low maintenance ECT utilization (13.2 %), approximately 40 % of ECT patients maintained stability over two years.CONCLUSIONS:Our findings described different long-term trajectories in TRS following CLZ or ECT as initial treatments, highlighting the importance of extended follow-up. Considering long-term stability, timely CLZ initiation is preferable. ECT can be a valuable alternative when CLZ implementation is impractical, providing clinical stability in a substantial proportion of patients.
DOI	10.1016/j.jpsychires.2025.09.004
PMID	40939570