論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Differences in P2Y12 Reaction Units Between Prasugrel and Clopidogrel by Ischemic Cerebrovascular Disease Subtypes　- Subanalysis From ACUTE-PRAS.
掲載誌名	正式名：Circulation reports 略　 称：Circ Rep ISSNコード：24340790/24340790
掲載区分	国外
巻・号・頁	7(9),pp.817-825
著者・共著者	Shigeru Fujimoto, Yasuyuki Iguchi, Hiroshi Yamagami, Masatoshi Koga, Ryo Itabashi, Yusuke Yakushiji, Kazuma Kowata, Naoto Kimura, Yuka Terasawa, Takahiro Shimizu, Yuichi Miyazaki, Koichi Oki, Osamu Masuo, Hideki Matsuoka, Shuji Arakawa, Toshihiro Ueda, Ryota Tanaka, Wataru Hashimoto, Satoru Abe, Go Kato, Taketoshi Furugori, Kazumi Kimura,
発行年月	2025/07
概要	BACKGROUND:We previously reported that prasugrel treatment resulted in stable inhibition of platelet aggregation compared with clopidogrel in patients with acute large artery atherosclerosis (LAA) or high-risk transient ischemic attack (TIA). However, the differences by disease subtypes were not assessed. This subgroup analysis of the open-label ACUTE-PRAS study examined differences in P2Y12 reaction units between prasugrel and clopidogrel by disease subtypes (acute LAA and high-risk TIA).METHODS AND RESULTS:We measured platelet reaction units (PRU) by disease subtypes for each treatment arm. Eighty-eight patients were included in each treatment arm in the full analysis. In the prasugrel group, there were 61 (69.3%) patients with LAA and 27 (30.7%) patients with high-risk TIA. In the clopidogrel group, there were 64 (72.7%) patients with LAA and 24 (27.3%) patients with high-risk TIA. Among patients with LAA, PRU at Day 5 were numerically lower in the prasugrel group than in the clopidogrel group (arithmetic mean±standard deviation at Day 5: 128.8±49.0 vs. 178.9±60.5). In contrast, PRU at Day 5 were similar between prasugrel and clopidogrel in patients with high-risk TIA.CONCLUSIONS:Prasugrel may have the potential to elicit stronger platelet aggregation inhibitory effects compared with clopidogrel in patients with acute LAA.
DOI	10.1253/circrep.CR-25-0077
PMID	40937038