| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Comparison of autologous and allogeneic hematopoietic stem cell transplantation for primary plasma cell leukemia in Japan. |
| 掲載誌名 | 正式名：Transplantation and cellular therapy 略 称：Transplant Cell Ther ISSNコード：26666367/26666367 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Masaya Megaki, Tsutomu Takahashi, Kazuhito Suzuki, Daisuke Minakata, Toshiki Terao, Atsushi Satake, Hangaishi Akira, Tatsuo Oyake, Yoshinobu Kanda, Nobuyuki Aotsuka, Nobuhiro Tsukada, Takayuki Tabayashi, Hikaru Kobayashi, Yuichiro Nawa, Tatsuo Ichinohe, Marie Ohbiki, Yoshiko Atsuta, Koji Kawamura |
| 発行年月 | 2025/09 |
| 概要 | Primary plasma cell leukemia (pPCL) is a rare and aggressive subtype of plasma cell malignancy. Although hematopoietic stem cell transplantation (HCT), including autologous HCT (auto-HCT) and allogeneic HCT (allo-HCT), is widely used, an optimal treatment strategy is undetermined. We retrospectively analyzed patients with pPCL who underwent HCT between 2006 and 2022 in Japan using Japanese registry data. Overall, 182 patients (117 and 65 who underwent auto-HCT and allo-HCT, respectively) were included. Patients in the allo-HCT group were younger, had more advanced disease, and underwent tandem HCT more frequently than did those in the auto-HCT group. There was no statistically significant difference in overall survival (OS) between the groups (P=0.46), with a median OS of 3.2 years (95% CI 2.1-4.3 years) in the auto-HCT group and 1.4 years (95% CI 0.8-3.9 years) in the allo-HCT group. Comparing the four different transplantation strategies (single auto-HCT, single allo-HCT, tandem autologous-autologous HCT, and tandem autologous-allogeneic HCT), the single allo-HCT group had the poorest OS because of early mortality. Tandem autologous-allogeneic HCT appeared to provide better long-term survival. In the multivariate analysis, disease status, Eastern Cooperative Oncology Group Performance Status, and tandem transplantation were significant factors influencing OS. A matched-pair analysis using propensity scores revealed no significant differences in OS between the auto-HCT and allo-HCT groups. However, the allo-HCT group appeared to have better long-term survival than the auto-HCT group. Allogeneic transplantation, including tandem autologous-allogeneic-HCT, may offer long-term survival benefits with appropriate patient selection. Further studies are warranted to optimize the transplantation strategies and pre- and post-transplantation treatments for pPCL. |
| DOI | 10.1016/j.jtct.2025.08.026 |
| PMID | 40930225 |