論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Gastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis.
掲載誌名	正式名：Journal of translational medicine 略　 称：J Transl Med ISSNコード：14795876/14795876
掲載区分	国外
巻・号・頁	23(1),pp.1039
著者・共著者	Tsubasa Shimogama, Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Yusuke Honzawa, Toshiro Fukui, Makoto Naganuma
発行年月	2025/10
概要	OBJECTIVE:Increasing evidence indicated substantial involvement of non-Helicobacter pylori microbiota in gastric tumorigenesis. We aimed to elucidate detailed relationship of microbiome dynamics between two different steps in gastric cancer (GC) such as cancer initiation and progression, and assessed their associations with clinicopathological and molecular changes.METHODS:We systemically characterized gastric microbiome during GC initiation and progression using 944 biopsies from primary GC, non-cancerous gastric mucosa from both GC and non-cancer subjects. The association between specific microbial characteristics and GC risk, prognosis and molecular changes such as TP53 mutation, DNA methylation and telomere shortening were also evaluated.RESULTS:Microbial α-diversity in the gastric mucosa was decreased in relation to the GC occurrence, while it increased in primary GC tissue. Such paradoxical change was also observed in specific groups of bacteria during GC occurrence and its progression. GC risk-related microbiome was associated with differentiated GC, severe intestinal metaplasia, associated DNA methylation and telomere shortening, while GC tissue-specific microbiome was associated with more aggressive features of GC and TP53 mutation status.CONCLUSIONS:Our findings suggested the different role of non-Helicobacter pylori microbiota in GC initiation and progression steps.
DOI	10.1186/s12967-025-07046-5
PMID	41035034