| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Effect of Topical Application of Povidone-Iodine on the Number of Bacteria Entering the Lower Respiratory Tract of Intubated Patients: A Randomized Controlled Trial. |
| 掲載誌名 | 正式名：Cureus 略 称：Cureus ISSNコード：21688184/21688184 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 17(8),pp.e91274 |
| 著者・共著者 | Yuki Sakamoto, Arisa Tanabe, Yuri Uchida, Makiko Moriyama, Madoka Funahara, Akira Imakiire, Sakiko Soutome, Yuka Kojima |
| 発行年月 | 2025/08 |
| 概要 | OBJECTIVE:The aim of the study was to evaluate and compare the efficacy of povidone-iodine (PI) oral care and toothbrushing in reducing the number of viable bacteria in subglottic secretions of intubated patients.METHODS:This open-label randomized controlled trial included 20 ICU patients undergoing mechanical ventilation. Patients were assigned to either the PI or the toothbrushing groups. Subglottic secretions were collected immediately before oral care (baseline) and at 1, 2, 3, and 6 hours after the intervention. Viable bacterial counts were quantified using delayed real-time polymerase chain reaction. The Mann-Whitney U test was used for statistical comparison.RESULTS:The PI group showed significant reductions in bacterial counts at 2, 3, and 6 hours after care (p=0.023, 0.002, and <0.001, respectively), whereas the toothbrushing group did not show significant changes.CONCLUSION:PI oral care effectively reduces viable bacterial load in the lower respiratory tract and may serve as a safe and cost-effective alternative to chlorhexidine for ventilator-associated pneumonia prevention in Japan. |
| DOI | 10.7759/cureus.91274 |
| PMID | 41030697 |