論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians.
掲載誌名	正式名：iScience 略　 称：iScience ISSNコード：25890042/25890042
掲載区分	国外
巻・号・頁	28(10),pp.113535
著者・共著者	Kimura Y, Suzuki M, Okumura A, Matsunami M, Nishide H, Mizuno R, Bou K, Uno Y, Nakada T, Hasunuma I, Haramoto Y, Fukui A, Inoue T, Sato Y, Yamaguchi K, Zhang Z, Chihara A, Takehara M, Shibata Y, Kitada M, Moreno N, Uchiyama I, Suzuki Y, Takeuchi T, Nikaido M, Agata K, Toyoda A, Shigenobu S, Hayashi T, Suzuki KT
発行年月	2025/10
概要	Salamanders provide excellent models for studying vertebrate evolution, development, and regeneration. To further advance the newt as a model organism in biology, we conducted draft genome sequencing of 20 Gb of an inbred newt (Pleurodeles waltl). As part of this study, the Hoxd11-d13 intergenic region is expanded by over 1 Mb owing to the massive insertion of repetitive sequences including newt-specific satellite DNA. Interestingly, Myod and Bmp4, genes that are typically involved in vertebrate development, are absent in salamanders. Co-option of Sodefrin Precursor-like Factor genes, which encode sex pheromone ligands, suggests a diversification of reproductive behavior among salamanders. Moreover, a limb enhancer of Shh, MFCS1/ZRS, retains its function, even though it is positioned approximately 5 Mb away from the promoter. Furthermore, we have identified a functional cis-element potentially associated with limb regeneration in this enhancer. The newt genome yields crucial insights into amphibian evolution, behavior, development, and regeneration.
DOI	10.1016/j.isci.2025.113535
PMID	41069852