論文種別	症例報告
言語種別	英語
査読の有無	その他(不明)
表題	Elderly-onset iatrogenic cerebral amyloid angiopathy presenting with lobar and deep haemorrhages.
掲載誌名	正式名：BMJ case reports 略　 称：BMJ Case Rep ISSNコード：1757790X/1757790X
掲載区分	国外
巻・号・頁	18(10),pp.e267435
著者・共著者	Hiroki Sakamoto, Aya Murakami, Yumiko Kono, Masataka Nakamura, Koichiro Higasa, Yusuke Yakushiji
発行年月	2025/10
概要	A man in his 60s, with no vascular risk factors, was referred for recurrent intracerebral haemorrhages. He had a subarachnoid haemorrhage in his 20s and underwent craniotomy for a right internal carotid artery aneurysm, with no record of a cadaveric dura graft. 35 years later, he experienced a right temporal lobar haemorrhage, followed by a left thalamic haemorrhage 6 months later in his 60s. A brain MRI could not be performed due to unknown materials from the previous clipping. Although over 55, his history of neurosurgery, negative genetic analysis for Alzheimer's and positive PET/CT for amyloid led to a diagnosis of iatrogenic cerebral amyloid angiopathy (CAA), which is more commonly observed in patients under 55. Given the thalamic haemorrhage, usually not associated with CAA, he would typically be diagnosed with hypertensive cerebral haemorrhage. This indicates that some patients diagnosed as hypertensive haemorrhage may actually represent iatrogenic CAA.
DOI	10.1136/bcr-2025-267435
PMID	41062125