論文種別	総説
言語種別	英語
査読の有無	その他(不明)
表題	Lung Cancers in Never-Smokers: A Different Disease?
掲載誌名	正式名：Surgical oncology clinics of North America 略　 称：Surg Oncol Clin N Am ISSNコード：15585042/10553207
掲載区分	国外
巻・号・頁	34(4),pp.543-556
著者・共著者	Michelle C Salazar, Aki Katarina Kobayashi
発行年月	2025/10
概要	Lung cancer in never-smokers is a distinct clinical and molecular entity, with unique epidemiology, risk factors, and tumor biology. As smoking declines, the proportion of patients with lung cancer who have never smoked has increased. Women have been more affected given their low smoking rates. Adenocarcinoma is the predominant subtype, often driven by actionable mutations like epidermal growth factor receptor, making molecular profiling essential. Environmental exposures, genetics, and hormonal influences may contribute to risk. Never-smokers typically respond poorly to immunotherapy but benefit significantly from targeted therapies.
DOI	10.1016/j.soc.2025.05.001
PMID	41110872