| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial. |
| 掲載誌名 | 正式名：Geriatrics & gerontology international 略 称：Geriatr Gerontol Int ISSNコード：14470594/14470594 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Taku Fujimoto, Hiroshi Akasaka, Yukiko Yasunobe, Shino Yoshida, Yuri Onishi, Tomohiro Minami, Ken Terashima, Mari Shirai, Masaaki Isaka, Minoru Tanaka, Ken Sugimoto, Hiroshi Koriyama, Yoichi Takami, Makoto Yamasaki, Kotaro Yamashita, Takehiro Noda, Hidekazu Takahashi, Hidetoshi Eguchi, Yuichiro Doki, Hiromi Rakugi, Koichi Yamamoto |
| 発行年月 | 2025/10 |
| 概要 | AIM:To investigate the impact of preoperative exercise and nutritional interventions on postoperative complications, physical function, and activities of daily living (ADL) 1 year postoperatively in frail older patients with gastrointestinal cancer.METHODS:This single-center, randomized controlled trial enrolled 62 patients aged ≥ 70 years scheduled to undergo elective surgery for gastrointestinal cancer with decreased grip strength or walking speed between October 2017 and December 2022. Participants were randomly assigned to control (n = 33) and intervention (n = 29) groups; the latter performed resistance exercises and consumed amino acid-containing jelly daily at home for 14 days. All participants were followed-up for 1 year.RESULTS:After exclusion, 27 and 18 patients were enrolled in the control and intervention groups, respectively. The average age was 80.4 years, and 37.8% were male. Postoperative complications were observed in 51.9% and 44.4% of the control and intervention groups, respectively (95% confidence interval [CI] 0.62-2.19), with postoperative delirium observed in 25.9% and 33.3%, respectively (95% CI 0.31-1.94). There were no significant inter-group differences in grip strength, walking speed, or skeletal muscle index. However, the intervention group showed superior knee extension strength maintenance (preoperatively: 100.2% ± 18.3% vs. 119.1% ± 68.8%, p = 0.19; discharge: 86.7% ± 22.0% vs. 119.3% ± 72.0%, p = 0.044), and lower rates of decreased ADLs or death 1 year postoperatively (42.3% vs. 23.5%; RR 0.56, 95% CI 0.08-1.92).CONCLUSIONS:This 14-day preoperative exercise and nutritional intervention program did not significantly reduce postoperative complications in frail older patients with gastrointestinal cancer; however, it aided in maintaining knee extension strength at discharge. |
| DOI | 10.1111/ggi.70226 |
| PMID | 41108598 |