論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Short-Term Efficacy of Two-Step Treatment of Retinopathy of Prematurity in a Japanese Cohort: Anti-VEGF Therapy Followed by Routine Laser Photocoagulation.
掲載誌名	正式名：Journal of clinical medicine 略　 称：J Clin Med ISSNコード：20770383/20770383
掲載区分	国外
巻・号・頁	14(19),pp.7094
著者・共著者	Shimpei Oba, Tatsunori Kiriishi, Masatoshi Omi, Yuki Hattori, Hidetsugu Mori, Masayuki Ohnaka, Takeshi Hoshino, Haruhiko Yamada, Hisanori Imai
発行年月	2025/10
概要	Objective: The aim of this study was to assess the efficacy of laser photocoagulation (LPC) combined with anti-vascular endothelial growth factor (VEGF), in comparison with routine LPC monotherapy, in the treatment of retinopathy of prematurity (ROP). Methods: This retrospective study included data from 142 eyes treated according to the standard criteria of the Early Treatment for Retinopathy of Prematurity (ETROP). Group A patients had received LPC alone, and Group B had received anti-VEGF therapy followed by routine LPC. Group B was further categorized into two subgroups: Groups B1 and B2 had received bevacizumab and ranibizumab, respectively. Data collected included ROP stage, gestational week, postmenstrual week, birth weight, number of laser spots and sessions. Results: Group B required significantly fewer laser spots than was the case with Group A (Group A: 583.0 ± 350.72, Group B: 274.9 ± 124.77, p < 0.0001). The number of LPC sessions differed significantly between the groups (Group A: 1.8 ± 1.28, Group B: 1.2 ± 0.45, p = 0.0003). Conclusions: Combining anti-VEGF therapy with routine LPC reduced the number of laser spots required. This approach offers an effective treatment strategy for managing severe ROP, potentially reducing long-term complications associated with extensive laser use.
DOI	10.3390/jcm14197094
PMID	41096174