論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Urothelial collective-gliding response acts as a toll-like receptor 4-associated defense mechanism.
掲載誌名	正式名：iScience 略　 称：iScience ISSNコード：25890042/25890042
掲載区分	国外
巻・号・頁	28(10),pp.113553
著者・共著者	Ning Zhang, Takeshi Sano, Katsuhiro Ito, Shinji Ito, Ryosuke Ikeuchi, Hideaki Takada, Kenji Nakamura, Toru Sakatani, Akihiro Hamada, Masashi Takeda, Kaoru Murakami, Yuki Kita, Takayuki Sumiyoshi, Takayuki Goto, Ryoichi Saito, Osamu Ogawa, Michiyuki Matsuda, Takashi Kobayashi
発行年月	2025/09
概要	Collective cell migration (CCM) is characterized by the coordinated movement of cell groups while maintaining cell-to-cell cohesion. Despite extensive research on CCM, the collective migration of mature epithelial cells over the extracellular matrix in response to external stimuli has not been reported. Using intravital imaging in mice, we identified urothelial CCM (UCCM) triggered by immunogenic substances, including bladder cancer cells (MB49) and uropathogenic Escherichia coli (UPEC). Integrin signaling inhibitors suppress UCCM, significantly enhancing MB49 tumor growth and UPEC bladder infection. UCCM initiation involves Toll-like receptor 4 (TLR4), we designated this TLR4-associated UCCM as the urothelial collective-gliding response (UCGR). Downstream of integrin signaling, urothelial matrix metalloproteinases (MMP)-8 and MMP-9 mediate UCGR. Intravesical instillation of these factors accelerates UCCM and inhibits tumor growth and infection. UCGR may represent a TLR4-associated defense mechanism, offering potential therapeutic strategies for bladder disorders such as refractory cystitis and recurrent non-muscle invasive bladder cancer after endoscopic resection.
DOI	10.1016/j.isci.2025.113553
PMID	41079633