論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	mTORC1-Independent IgA Production: A Unique Pathway for Gut Immune Homeostasis.
掲載誌名	正式名：International immunology 略　 称：Int Immunol ISSNコード：14602377/09538178
掲載区分	国外
巻・号・頁	38(3),pp.185-196
著者・共著者	Masashi Ohtani, Hideki Fujii, Takashi Watanabe, Osamu Ohara, Mikako Maruya, Sidonia Fagarasan, Takayuki Hoshii, Atsushi Hirao, Shigeo Koyasu, Masato Kubo, Satoshi Matsuda
発行年月	2026/03
概要	The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) regulates various cellular processes, including immune responses. Previous studies have demonstrated that mTORC1 plays a crucial for B cell differentiation and the production of IgM and IgG antibodies in response to foreign antigens. However, its role in steady-state antibody production remains poorly understood. In this study, we found that RaptorB-/- mice, which have a B cell-specific deletion of Raptor (an essential component of mTORC1), retained gut-associated IgA production. Conversely, IgM and IgG subclasses were virtually absent due to the loss of peripheral IgM+ mature B cells. We also found that IgA-producing cells were driven by the gut microbiota and were primarily localized in the intestinal lamina propria of RaptorB-/- mice. Consistently, IgA produced in RaptorB-/- mice was functional in its ability to bind gut bacteria and contributed to maintaining gut microbiota α-diversity, although its repertoire was restricted compared with that of control mice. Our findings demonstrated a distinct population of IgA-producing cells that develop independently of mTORC1 and contribute to gut homeostasis, thereby distinguishing them from conventional IgM- and IgG-producing cells.
DOI	10.1093/intimm/dxaf063
PMID	41122976