論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	mTORC1-Independent IgA Production: A Unique Pathway for Gut Immune Homeostasis.
掲載誌名	正式名：International immunology 略　 称：Int Immunol ISSNコード：14602377/09538178
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Masashi Ohtani, Hideki Fujii, Takashi Watanabe, Osamu Ohara, Mikako Maruya, Sidonia Fagarasan, Takayuki Hoshii, Atsushi Hirao, Shigeo Koyasu, Masato Kubo, Satoshi Matsuda
発行年月	2025/10
概要	The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) regulates various cellular processes, including immune responses. Previous studies have demonstrated that mTORC1 plays a crucial for B cell differentiation and the production of IgM and IgG antibodies in response to foreign antigens. However, its role in steady-state antibody production remains poorly understood. In this study, we found that RaptorB-/- mice, which have a B cell-specific deletion of Raptor (an essential component of mTORC1), retained gut-associated IgA production. Conversely, IgM and IgG subclasses were virtually absent due to the loss of peripheral IgM+ mature B cells. We also found that IgA-producing cells were driven by the gut microbiota and were primarily localized in the intestinal lamina propria of RaptorB-/- mice. Consistently, IgA produced in RaptorB-/- mice was functional in its ability to bind gut bacteria and contributed to maintaining gut microbiota α-diversity, although its repertoire was restricted compared with that of control mice. Our findings demonstrated a distinct population of IgA-producing cells that develop independently of mTORC1 and contribute to gut homeostasis, thereby distinguishing them from conventional IgM- and IgG-producing cells.
DOI	10.1093/intimm/dxaf063
PMID	41122976