| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Association between serum omentin-1 concentrations and body composition measured by dual-energy X-ray absorptiometry in Japanese elementary school-aged children. |
| 掲載誌名 | 正式名：Journal of physiological anthropology 略 称：J Physiol Anthropol ISSNコード：18806805/18806791 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 44(1),pp.29 |
| 著者・共著者 | Yuki Murakami, Yuki Fujita, Kumiko Ohara, Harunobu Nakamura, Masayuki Iki, Katsuyasu Kouda |
| 発行年月 | 2025/11 |
| 概要 | BACKGROUND:Omentin-1 (also known as intelectin-1) is a novel adipokine associated with metabolic diseases. However, its physiological role in body composition remains incompletely understood. Therefore, this study aimed to investigate the association between the circulating omentin-1 levels and whole-body and regional body composition parameters measured using dual-energy X-ray absorptiometry (DXA).METHODS:A population-based cross-sectional survey was conducted among school-aged children in Hamamatsu, Japan. Serum adipokine levels were measured using enzyme-linked immunosorbent assay, and associations between omentin-1 levels and DXA-based parameters were evaluated by multiple regression analysis after adjusting for potential confounding factors.RESULTS:The final study included 392 participants (192 boys, 200 girls, 75.2% of the source population; mean age 11.2 ± 0.3 years). Serum omentin-1 levels showed a significantly inverse association with nearly all DXA-based fat mass parameters. Inverse correlations were observed with fat-free soft tissue mass and serum leptin levels, whereas positive correlations were noted with adiponectin levels. The mean values for various body fat parameters, fat-free soft tissue mass, body mass index, and waist circumference were significantly decreased across tertiles of serum omentin-1 levels from lowest to the highest after adjusting for potential confounders.CONCLUSION:Our results demonstrate that Japanese school-aged children with higher fat mass tended to have lower serum omentin-1 levels. These findings provide crucial insights into the link between omentin-1 levels and body composition, which may contribute to early health interventions for metabolic improvement. |
| DOI | 10.1186/s40101-025-00406-6 |
| PMID | 41204367 |