| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer. |
| 掲載誌名 | 正式名：Journal of gastroenterology 略 称：J Gastroenterol ISSNコード：14355922/09441174 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Ryotaro Matsumoto, Kazuhiro Kikuta, Tetsuya Takikawa, Yousuke Nakai, Mamoru Takenaka, Kentaro Oki, Eizaburo Ohno, Ken Ito, Nao Fujimori, Akio Katanuma, Atsuhiro Masuda, Yasuki Hori, Tsukasa Ikeura, Rei Suzuki, Satoshi Yamamoto, Yoshio Sogame, Hiroki Kawashima, Tetsuhide Ito, Kosuke Okuwaki, Takao Itoi, Yukiko Takayama, Akira Nakamura, Shuji Terai, Kazuyuki Matsumoto, Masaki Kuwatani, Masashi Kishiwada, Minoru Shigekawa, Tomoaki Matsumori, Osamu Inatomi, Waku Hatta, Atsushi Irisawa, Michiaki Unno, Yoshifumi Takeyama, Atsushi Masamune, |
| 発行年月 | 2025/11 |
| 概要 | BACKGROUND/OBJECTIVE:Since the 2010s, Japan's national health insurance system has covered key management for chronic pancreatitis (CP), including pancreatic enzyme replacement therapy. These therapies are expected to improve long-term prognosis; however, recent data are lacking. This study aimed to clarify the updated cancer risk and mortality among patients with CP in Japan.METHODS:We conducted a multicenter, retrospective cohort study on 1,110 patients with CP treated at 28 institutions in 2011. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were calculated for comorbidities. Factors associated with the development of malignancy and overall survival were analyzed.RESULTS:Patients with CP had an elevated SIR of 1.62 (95% confidence interval [CI], 1.43-1.83) for malignancy, with the highest risk observed for pancreatic cancer (SIR = 6.44 [95% CI, 4.64-8.90]). During follow-up, 143 patients (12.9%) died, most frequently from malignancy (47.5%). The SMR was elevated in all patients with CP (SMR = 1.20 [95% CI, 1.01-1.42]) and in those with alcohol-related CP (SMR = 1.49 [95% CI, 1.23-1.81]) but not in those with alcohol-unrelated CP. Pancreatic cancer was identified as the strongest factor associated with overall survival (hazard ratio, 48.92 in multivariate analysis). Overall survival of the patients with pancreatic cancer was significantly longer in those who underwent regular examinations for CP at least every three months (P = 0.011).CONCLUSIONS:Patients with alcohol-related CP have higher mortality than the general population in Japan. Pancreatic cancer remains a crucial prognostic factor in patients with CP. Regular surveillance for pancreatic cancer is important to improve their prognosis. |
| DOI | 10.1007/s00535-025-02321-0 |
| PMID | 41251799 |