| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | A multicenter study of CT findings in medication-related osteonecrosis of the jaw. |
| 掲載誌名 | 正式名：Scientific reports 略 称：Sci Rep ISSNコード：20452322/20452322 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 15(1),pp.40152 |
| 著者・共著者 | Mitsunobu Otsuru, Keisuke Omori, Takumi Hasegawa, Yoshiko Yamamura, Eiji Kondo, Nobuhiro Ueda, Sakiko Soutome, Satoshi Rokutanda, Masamichi Ueda, Hirokazu Nakahara, Kenichiro Ishibashi, Eiji Iwata, Sachiko Yamasaki, Tomohiro Sado, Yoshinari Myoken, Yuki Sakamoto, Masashi Kobayashi, Tomoaki Hamana, Yuka Kojima, Taku Kanda, Misa Sumi, Akira Taguchi, Masahiro Umeda |
| 発行年月 | 2025/11 |
| 概要 | Medication-related osteonecrosis of the jaw is currently classified only by clinical staging, with no imaging-based qualitative classification available. To establish foundational data for a new classification method that could help guide treatment decisions and predict prognosis, this study investigated the computed tomography findings commonly observed in patients with medication-related osteonecrosis of the jaw and their frequencies. Computed tomography scans from 784 patients across 19 medical institutions were analyzed for the presence of osteolysis, sequestrum separation, periosteal reactions, mixed-type osteosclerosis, and the bone-within-bone appearance. Clinical factors associated with each finding were also examined. Osteolysis appeared as localized in 55.1% of cases, extended in 27.7%, and advanced in 13.8%. In contrast, 3.4% of patients showed no osteolysis. This non-osteolytic pattern was more common among patients treated with denosumab. Sequestrum separation was seen in 34.7% of patients, most frequently among those with osteoporosis. Periosteal reactions were observed in 5.9% of cases as the attached type, 12.4% as the gap type, and 5.6% as the irregular type. Mixed-type osteosclerosis occurred in 31.9% of cases, most often in the mandibles of patients with malignant tumors. The bone-within-bone appearance was observed in 3.1% of cases. Patients with sequestrum separation had more favorable treatment outcomes. In contrast, those without osteolysis and those with periosteal reactions, mixed-type osteosclerosis, or bone-in-bone appearance were more likely to have poorer outcomes. This multicenter study clarified the prevalence of several key computed tomography features in medication-related osteonecrosis of the jaw, highlighting their potential relevance to clinical outcomes. These findings lay the groundwork for future research into their prognostic and therapeutic implications to support the development of a new imaging-based classification system. |
| DOI | 10.1038/s41598-025-23915-x |
| PMID | 41249244 |