論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Diagnostic agreement and limitations of the Banff automated system in kidney transplant biopsies.
掲載誌名	正式名：Frontiers in nephrology 略　 称：Front Nephrol ISSNコード：28130626/28130626
掲載区分	国外
巻・号・頁	5,pp.1645280
著者・共著者	Jun Matsushita, Toshihito Hirai, Tomokazu Shimizu, Yu Kijima, Kohei Unagami, Masaaki Yanishi, Hidefumi Kinoshita, Toshio Takagi, Hideki Ishida
発行年月	2025/11
概要	The Banff classification for renal allograft rejection has evolved over time, increasing in complexity. For non-pathologists conducting retrospective studies, assigning Banff diagnostic categories across different eras presents a significant challenge. The Automated Diagnosis System (ADS) is a publicly available web-based tool designed to standardize Banff category diagnoses based on Banff scoring. We retrospectively evaluated ADS using 1,071 kidney biopsy results from 544 transplant recipients, including 146 ABO-incompatible cases performed at our institution. Overall concordance between ADS and pathologists was 69.8%, with high agreement in non-rejection (97.4%) and rejection (86.3%) cases. Among rejection cases, discrepancies were noted in 27 antibody-mediated rejection (AMR) and 22 T cell-mediated rejection (TCMR) cases. Discrepancies were frequently observed in AMR following ABO-incompatible transplantation and in chronic TCMR, highlighting challenges in standardizing these categories. Despite these limitations, ADS demonstrated acceptable concordance and potential utility for promoting global standardization in rejection diagnosis.
DOI	10.3389/fneph.2025.1645280
PMID	41358048