| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Complementary Use of Cachexia and Malnutrition Criteria Improves Prognostic Stratification in Patients with Advanced Cancer Receiving Palliative Care. |
| 掲載誌名 | 正式名：Clinical nutrition ESPEN 略 称：Clin Nutr ESPEN ISSNコード：24054577/24054577 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 71,pp.102884 |
| 著者・共著者 | Tatsuma Sakaguchi, Keisuke Maeda, Yuria Ishida, Mika Tsuchida, Koki Kawamura, Kaori Ohshita, Koji Amano, Naoharu Mori |
| 発行年月 | 2026/02 |
| 概要 | BACKGROUND & AIMS:Nutritional deterioration is highly prevalent in patients with advanced cancer, yet the diagnostic overlap and combined prognostic value of cachexia and malnutrition criteria remain unclear. This study aimed to investigate the consistency between the Asian Working Group for Cachexia (AWGC) and Global Leadership Initiative on Malnutrition (GLIM) criteria and their associations with overall survival (OS) in palliative care settings.METHODS:This retrospective cohort study included adult patients with advanced cancer referred to the palliative care team at Aichi Medical University Hospital between April 2019 and March 2024. Cachexia and malnutrition were diagnosed according to the AWGC and GLIM frameworks, incorporating both phenotypic and etiologic components. Patients were categorized into four groups based on diagnosis status: Group A (both cachexia and malnutrition), Group B (cachexia only), Group C (malnutrition only), and Group D (neither condition). OS was compared across groups using Kaplan-Meier analysis and Cox proportional hazards models adjusted for clinical covariates.RESULTS:Among 1,325 eligible patients, cachexia and malnutrition were diagnosed in 76% and 71%, respectively, with a 65% diagnostic overlap. Group A demonstrated the shortest median survival time (MST) at 74 days compared to 431 days in Group D (p < 0.0001). In multivariate analysis, only Group A diagnosis independently predicted poorer OS (hazard ratio [HR] 1.33, p < 0.001). Survival differences among Groups B, C, and D became evident only after excluding patients with edema (p = 0.008).CONCLUSION:Complementary application of the AWGC and GLIM criteria enhances prognostic stratification in patients with advanced cancer. Careful evaluation of fluid status is essential to optimize nutritional assessment and outcome prediction in this population. |
| DOI | 10.1016/j.clnesp.2025.102884 |
| PMID | 41421447 |