論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Curative approach for solitary liver metastasis presenting as a rare pattern of organ spread in testicular cancer: a case report.
掲載誌名	正式名：International cancer conference journal 略　 称：Int Cancer Conf J ISSNコード：21923183/21923183
掲載区分	国外
巻・号・頁	14(4),pp.486-492
著者・共著者	Sho Kiyota, Takashi Yoshida, Takahiro Nakamoto, Chisato Ohe, Yumiko Kono, Akiyo Kita, Yuki Masuo, Hidefumi Kinoshita
発行年月	2025/08
概要	Solitary liver metastasis is an uncommon presentation of metastatic testicular cancer. This report details the case of a 16-year-old boy who presented with high fever and slight enlargement of the left testicle. Imaging revealed para-aortic regional lymph node swelling and a large liver mass occupying most of the left lobe. Left radical inguinal orchiectomy was performed, followed by liver biopsy to distinguish between a primary tumor and distant metastasis. Histopathological analysis confirmed a mixed non-seminomatous germ cell tumor with liver metastasis. The patient underwent four cycles of combination chemotherapy with bleomycin, etoposide, and cisplatin, followed by two additional cycles of etoposide, ifosfamide, and cisplatin, until tumor marker negativity was confirmed. Despite chemotherapy, clinically significant residual masses remained in the regional lymph nodes and liver. Detailed imaging evaluation suggested that liver metastasis had occurred through mesenteric vein infiltration by para-aortic lymph node metastasis. Retroperitoneal lymph node dissection was performed, revealing no evidence of malignancy, followed by liver metastasectomy. The patient achieved complete remission and has remained recurrence-free for 4 years since multimodal therapy. Even in the cases of liver metastases associated with poor prognosis, a comprehensive therapeutic approach that considers the metastatic pathway can achieve curative outcomes.
DOI	10.1007/s13691-025-00800-y
PMID	41395556