論文種別	症例報告
言語種別	英語
査読の有無	その他(不明)
表題	Neoantigen dendritic cell vaccination combined with conventional chemotherapy for a patient with advanced transverse colon cancer.
掲載誌名	正式名：Journal of surgical case reports 略　 称：J Surg Case Rep ISSNコード：20428812/20428812
掲載区分	国外
巻・号・頁	2026(1),pp.rjaf1030
著者・共著者	Hideya Onishi, Atsushi Higa, Mayu Tasaki, Yuki Inaoka, Aya Okuda, Yoshio Miki, Yasuaki Tsuchida, Hitoshi Hino, Masahiko Kawamoto, Shinya Ueda, Nobuyuki Takai, Koshiro Ando, Michiko Tani, Nobuyuki Tani, Tomoki Ito, Hisakazu Yamagishi, Yusuke Nakamura, Kohji Tani
発行年月	2026/01
概要	Over the past decade, neoantigen dendritic cell (DC) vaccination has emerged as a promising personalized cancer immunotherapy based on genomic analysis. To further assess the clinical utility of this approach, additional data on the efficacy of neoantigen DC vaccination are needed. A 65-year-old male patient underwent curative surgical resection for pStage IIIB transverse colon cancer, followed by adjuvant DC vaccination combined with conventional chemotherapy for 6 months postoperatively. The neoantigen DC vaccination effectively reduced elevated carcinoembryonic antigen levels. Moreover, cytotoxic T lymphocytes (CTLs) isolated from the patient's peripheral blood demonstrated specific recognition of the neoantigen peptides. Our findings suggest that CTLs recognizing tumor-specific neoantigens may play an important role in immune surveillance against cancer recurrence. The patient remains alive and disease-free 16 months after surgery.
DOI	10.1093/jscr/rjaf1030
PMID	41503128