論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Development of a Peptide-Based Photoimmunotherapy Drug Targeting PD-L1.
掲載誌名	正式名：Molecules 略　 称：Molecules ISSNコード：14203049
掲載区分	国外
巻・号・頁	31(2),pp.302
著者・共著者	Takuya Otani, Naoya Kondo, Ayaka Kanai, Hirofumi Hanaoka
発行年月	2026/01
概要	Near-infrared photoimmunotherapy (NIR-PIT) has recently attracted attention as a highly selective cancer treatment, with good treatment outcomes observed from the only antibody-based drug currently available for clinical use. However, since only a single agent is currently used clinically and the development of new antibodies is costly, exploring other therapeutic modalities is important. In this study, we investigated a novel peptide-based PIT drug targeting programmed death-ligand 1 (PD-L1), which is overexpressed in many types of cancer. The WL12 peptide, which is known to bind to PD-L1, was conjugated with the photoabsorber IRDye700DX (IR700), and its usefulness was evaluated in vitro and in vivo. In therapeutic experiments on PD-L1-positive cells, NIR-PIT with WL12-IR700 induced PIT-like morphological changes in cells and reduced cancer cell viability in an NIR light dose- and drug concentration-dependent manner. In vivo experiments showed significant suppression of tumor growth and an extended overall survival rate. These results indicate that the developed peptide-based drug can be used for PD-L1-targeted NIR-PIT.
DOI	10.3390/molecules31020302
PMID	41599351