| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Predictive Value of Notched P Wave for Life-Threatening Arrhythmias in Patients with Brugada Syndrome: Insights from a Multicenter Prospective Study. |
| 掲載誌名 | 正式名：Heart rhythm 略 称：Heart Rhythm ISSNコード：15563871/15475271 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Tetsuji Shinohara, Masahiko Takagi, Tsukasa Kamakura, Yuki Komatsu, Yoshiyasu Aizawa, Yukio Sekiguchi, Yasuhiro Yokoyama, Naohiko Aihara, Masayasu Hiraoka, Kazutaka Aonuma, |
| 発行年月 | 2026/03 |
| 概要 | BACKGROUND:Risk stratification for ventricular fibrillation (VF) in Brugada syndrome (BrS) remains a major clinical challenge. Atrial fibrillation is relatively common in BrS, suggesting that atrial conduction abnormalities may be related to arrhythmogenesis. A notched P wave on the surface electrocardiogram (ECG) reflects atrial conduction delay, but its prognostic significance for VF in BrS has not been fully established.OBJECTIVE:To evaluate the association between notched P waves and life-threatening arrhythmic events in patients with BrS.METHODS:We analyzed 510 patients with BrS (mean age, 51 ± 14 years; 95% men) enrolled in a prospective multicenter registry across 61 hospitals in Japan. Clinical and ECG parameters at enrollment were assessed, and patients were followed for cardiac events (VF, sustained ventricular tachycardia, or sudden cardiac death).RESULTS:During a mean follow-up of 107 ± 62 months, 58 patients (11%) experienced cardiac events. Notched P waves were present in 52 patients (10%). Patients with notched P waves had a significantly higher incidence of cardiac events compared with those without (27% vs. 10%, p < 0.001). Kaplan-Meier analysis demonstrated lower event-free survival in patients with notched P waves (p < 0.001). In multivariable Cox regression, a notched P wave remained an independent predictor of cardiac events (hazard ratio: 2.63; 95% CI: 1.35-4.78; p = 0.006), along with a history of VF.CONCLUSIONS:A notched P wave on a standard 12-lead ECG independently predicts life-threatening arrhythmias in BrS and may improve risk stratification by complementing conventional predictors. |
| DOI | 10.1016/j.hrthm.2026.03.004 |
| PMID | 41819241 |