| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Efficacy of olanzapine for prophylaxis of delayed chemotherapy-induced nausea and vomiting in patients with breast cancer receiving dose-dense AC with a steroid-sparing regimen: a single-center pilot study. |
| 掲載誌名 | 正式名：BMC cancer 略 称：BMC Cancer ISSNコード：14712407/14712407 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Manami Tada, Yuichiro Kikawa, Nobuhiro Shibata, Chie Hirai, Hirotsugu Yanai, Masahiro Takada, Tomoharu Sugie |
| 発行年月 | 2026/04 |
| 概要 | PURPOSE:This study examined the feasibility of a steroid-sparing approach in a dose-dense AC regimen in breast cancer patients, while integrating olanzapine to manage chemotherapy-induced nausea and vomiting (CINV).METHODS:A prospective, single-center study was conducted with 30 patients diagnosed with Stage I-III breast cancer who underwent treatment with a dose-dense AC regimen. Patients were given prophylactic olanzapine from days 1 to 4 along with the standard three-drug combination antiemetic regimen, excluding dexamethasone on days 2 and 3. Nausea, vomiting, and drowsiness were evaluated using a validated 4-point Likert scale. The main outcome measured was the complete response (CR) rate in the delayed phase.RESULTS:The CR rates were 73% and 63% in the acute and delayed phases, respectively. The total control and complete control rates in the acute phase were 60% and 73%, respectively, while in the delayed phase, they were 36.6% and 63%. Moderate-to-severe daytime sleepiness was observed in 40% of the patients. The mean nausea score on the EORTC QLQ-C30 remained within the minimally important difference threshold for all four treatment cycles.CONCLUSION:This study suggests that olanzapine may enable steroid reduction without compromising CINV control in patients receiving dose-dense AC. A steroid-sparing regimen could mitigate steroid-related adverse effects while maintaining antiemetic efficacy. Further large-scale studies are warranted to validate these findings and optimize steroid-sparing strategies in antiemetic protocols.TRIAL REGISTRATION:This study was registered on August 29, 2020, in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000041605). |
| DOI | 10.1186/s12885-026-15962-y |
| PMID | 41937180 |