| 論文種別 | 症例報告 |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | A Case of Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus Achieving Pathologic Complete Response Following Combination Therapy With Lenvatinib and Pembrolizumab. |
| 掲載誌名 | 正式名：IJU case reports 略 称：IJU Case Rep ISSNコード：2577171X/2577171X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 9(2),pp.e70165 |
| 著者・共著者 | Hiroki Takayama, Takeshi Sano, Kento Hirao, Yusuke Motoki, Hisanori Taniguchi, Masaaki Yanishi, Katsunori Uchida, Hidefumi Kinoshita |
| 発行年月 | 2026/03 |
| 概要 | INTRODUCTION:The efficacy of neoadjuvant lenvatinib plus pembrolizumab for clear cell renal cell carcinoma with inferior vena cava tumor thrombus remains unclear.CASE PRESENTATION:An 80-year-old man was diagnosed with clear cell renal cell carcinoma and tumor thrombus extending into the inferior vena cava. Following neoadjuvant lenvatinib plus pembrolizumab, the primary renal tumor shrank markedly, whereas the inferior vena cava tumor thrombus demonstrated only a slight reduction in size. Robot-assisted radical nephrectomy and lymphadenectomy were performed; however, conversion to open surgery was required because of an inferior vena cava laceration. Pathological examination revealed no residual viable cancer cells. The patient has remained free of recurrence for 1.5 years postoperatively.CONCLUSION:In this case, a pathological complete response was achieved following combination therapy of lenvatinib with pembrolizumab. |
| DOI | 10.1002/iju5.70165 |
| PMID | 41987766 |