| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 日本語 |
| 査読の有無 | 査読あり |
| 表題 | [A cohort study on cardiovascular diseases in adults with hemophilia: an interim subanalysis on comorbidities and medication from ADVANCE Japan]. |
| 掲載誌名 | 正式名：[Rinsho ketsueki] The Japanese journal of clinical hematology 略 称：Rinsho Ketsueki ISSNコード：04851439/04851439 |
| 巻・号・頁 | 66(11),1438-1448 |
| 著者・共著者 | Azusa Nagao, Yushi Chikasawa, Takeshi Kanematsu, Naoya Yamasaki, Masanori Nojima, Yukio Hiroi, Kagehiro Amano, Akihiro Sawada, Nobuaki Suzuki, Hideyuki Takedani, Satoshi Higasa, Teruhisa Fujii, Tadashi Matsushita |
| 発行年月 | 2025 |
| 概要 | INTRODUCTION:As life expectancy in hemophilia improves, chronic comorbidities and treatment-related challenges demand greater attention.OBJECTIVE:To characterize comorbidities, medication use, and cardiovascular risk factors in Japanese adults (≥40 years) with hemophilia enrolled in a prospective, multicenter cohort study (ADVANCE Japan cohort).METHODS:A subanalysis was conducted in participants who completed at least one follow-up visit between 2019 and 2023.RESULTS:Seventeen of the 599 participants died (2.8%), mainly from liver disease, intracranial hemorrhage, and malignancy. Thirty-two cancers were documented, with hepatocellular carcinoma being the most common. Compared with the general male population, hypertension was more common in the hemophilia cohort (OR 1.51, 95%CI: 1.17-1.93), whereas dyslipidemia (OR 0.48, 95%CI: 0.37-0.62), chronic kidney disease (OR 0.53, 95%CI: 0.38-0.76), obesity (OR 0.50, 95%CI: 0.40-0.64), and smoking (OR 0.74, 95%CI: 0.59-0.93) were less common. Non-steroidal anti-inflammatory drugs were frequently prescribed despite guideline recommendations, reflecting likely chronic pain from advanced hemophilic arthropathy. Four patients developed new factor VIII/IX inhibitors, including two without prior history.CONCLUSION:This interim analysis reveals distinctive patterns of comorbidity, medication use, and cardiovascular risk among aging Japanese adults with hemophilia, underscoring the need for tailored long-term care strategies. |
| DOI | 10.11406/rinketsu.66.1438 |
| PMID | 41354444 |