| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides. |
| 掲載誌名 | 正式名：Gut microbes 略 称：Gut Microbes ISSNコード：19490984/19490976 |
| 巻・号・頁 | 15(1),pp.2161271 |
| 著者・共著者 | Junki Miyamoto, Hidenori Shimizu, Keiko Hisa, Chiaki Matsuzaki, Shinsuke Inuki, Yuna Ando, Akari Nishida, Ayano Izumi, Mayu Yamano, Chihiro Ushiroda, Junichiro Irie, Takane Katayama, Hiroaki Ohno, Hiroshi Itoh, Kenji Yamamoto, Ikuo Kimura |
| 発行年月 | 2023 |
| 概要 | Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides-produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS. |
| DOI | 10.1080/19490976.2022.2161271 |
| PMID | 36604628 |