| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Three-factor Clinical Score for First-line Nivolumab Plus Ipilimumab in Metastatic Renal Cell Carcinoma. |
| 掲載誌名 | 正式名：Anticancer research 略 称：Anticancer Res ISSNコード：17917530/02507005 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 46(6),pp.3453-3459 |
| 著者・共著者 | Masaaki Yanishi, Takahiro Nakamoto, Takashi Yoshida, Takao Mishima, Hidefumi Kinoshita |
| 発行年月 | 2026/06 |
| 概要 | BACKGROUND/AIM:Nivolumab plus ipilimumab (NIVO-IPI) provides durable disease control in a subset of patients with metastatic renal cell carcinoma (mRCC). However, reliable clinical tools for identifying this patient population remain undefined. We aimed to develop a simple clinical score to stratify outcomes in real-world patients treated with first-line NIVO-IPI.PATIENTS AND METHODS:We conducted a multicenter retrospective analysis of 65 consecutive patients with untreated mRCC who received first-line NIVO-IPI. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and Cox proportional hazards model. Based on Cox regression findings and clinical interpretability, a three-factor clinical score was constructed assigning one point each for International Metastatic RCC Database Consortium (IMDC) poor risk (score ≥3), presence of bone metastasis, and elevated baseline C-reactive protein (CRP ≥1 mg/dl). Patients were stratified into three groups (scores 0, 1, and ≥2).RESULTS:Among the 65 patients included, the median PFS and OS were 10.1 and 35.3 months, respectively, and the 12-month PFS and OS rates were 41.9% and 75.5%, respectively. The three-factor score effectively stratified the outcomes. Median PFS was not reached, not reached, and 5.9 months in patients with scores 0, 1, and ≥2, respectively, with corresponding 12-month PFS rates of 72.9, 58.0, and 14.4%. Median OS was not reached, 36.5 months, and 16.8 months, with corresponding 12-month OS rates of 94.4, 92.9, and 54.7%.CONCLUSION:The developed three-factor clinical score incorporating IMDC risk, bone metastasis, and baseline CRP effectively stratified real-world patients treated with first-line NIVO-IPI. Patients without these risk factors achieved sustained disease control, whereas those with ≥2 risk factors had significantly inferior outcomes. This tool may assist in selecting patients most likely to derive durable benefits from NIVO-IPI in routine clinical practice. |
| DOI | 10.21873/anticanres.18213 |
| PMID | 42203341 |