論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Machine learning-based clinical tool for identifying factors associated with symptomatic knee osteoarthritis: the Nagahama study.
掲載誌名	正式名：The Knee 略　 称：Knee ISSNコード：18735800/09680160
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Masashi Taniguchi, Kaede Nakazato, Tome Ikezoe, Tadao Tsuboyama, Hiromu Ito, Shuichi Matsuda, Fumihiko Matsuda, Noriaki Ichihashi,
発行年月	2026/06
概要	BACKGROUND:A clinical tool that evaluates factors associated with symptomatic knee osteoarthritis (OA) based on modifiable factors is lacking. This study aimed to develop a machine learning-based clinical assessment tool using modifiable factors to identify factors associated with symptomatic knee OA and to determine its accuracy.METHODS:This study included 429 participants (81.8% women; age, 69.0 ± 5.3 years) from the Nagahama Study who were ≥60 years old and had radiographically confirmed knee OA. A Knee Society Knee Scoring System 2011 symptom score of <23 points defined symptomatic knee OA. Participants were randomly assigned to training (70%) and test (30%) datasets. A machine learning model was developed using Extreme Gradient Boosting with 27 variables, and the SHapley Additive exPlanation (SHAP) values were used to assess feature importance. The top 8 features were translated into a 100-point clinical scoring tool weighted by their SHAP contributions. The cutoff value indicating symptomatic knee OA in the clinical assessment tool was determined using receiver operating characteristic analysis, and model performance was evaluated in both datasets.RESULTS:The clinical assessment tool consisted of low back pain, OA severity, depressive tendencies, knee flexion/extension range of motion, knee extension and hip abduction strength, and lower limb muscle quality. The model showed moderate discriminative performance (AUC 0.771 and 0.773 in the training and test datasets, respectively), with a cutoff point of 47.CONCLUSION:The proposed clinical assessment tool may provide a structured framework for assessing modifiable factors associated with symptomatic knee OA, reflecting their contribution to current symptom status.
DOI	10.1016/j.knee.2026.104525
PMID	42269236