論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Therapeutic potential of photoimmunotherapy in solid tumors expressing CD98 heavy chain.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Citra R A P Palangka, Naoya Kondo, Ayaka Kanai, Hirofumi Hanaoka
発行年月	2026/06
概要	Near-infrared photoimmunotherapy (NIR-PIT) is an emerging targeted cancer therapy that uses an antibody-photoabsorber conjugate. In this study, we evaluated the therapeutic potential of NIR-PIT targeting CD98 heavy chain (CD98hc), a transmembrane glycoprotein that is highly expressed in various solid tumors and is associated with poor prognosis. We prepared a conjugate of the clinically tested anti-CD98hc antibody IGN523 and photoabsorber IRDye700DX (IGN523-IR700). The therapeutic efficacy was assessed in vitro using four CD98hc-expressing cancer cell lines and in an in vivo tumor xenograft mouse model. In vitro, IGN523-IR700 binds to cancer cells and induces rapid and light dose-dependent cell death upon near-infrared light exposure. In the in vivo model, intravenous administration of IGN523-IR700 followed by tumor-directed light irradiation resulted in significant tumor growth inhibition compared with that in the control groups. These results demonstrate that CD98hc is a viable and effective target for NIR-PIT. Given its widespread expression, targeting CD98hc may significantly broaden the applicability of NIR-PIT to diverse cancer types.
DOI	10.1038/s41598-026-57005-3
PMID	42265301