| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis. |
| 掲載誌名 | 正式名：Geriatrics & gerontology international 略 称：Geriatr Gerontol Int ISSNコード：14470594/14470594 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(6),pp.e70597 |
| 著者・共著者 | Shohei Hakozaki, Koichiro Matsumura, Shun Morishita, Junko Morimoto, Satoshi Kurose, Kazuyoshi Kakehi, Kosuke Fujita, Takayuki Kawamura, Eijiro Yagi, Hiroki Matsuzoe, Masafumi Ueno, Yutaka Kimura, Gaku Nakazawa |
| 発行年月 | 2026/06 |
| 概要 | AIM:To investigate the association between social frailty and sarcopenia and their combined effect on clinical outcomes in outpatients with stage B heart failure (HF).METHODS:This post hoc analysis of the PAPRIKA-HF study included 331 patients aged ≥ 65 years with stage B HF. Patients were stratified into three groups based on social frailty and sarcopenia. The primary outcome was a 2-year composite of all-cause death, myocardial infarction, and HF hospitalization.RESULTS:Of 308 patients, 189 (61%) had social frailty. Sarcopenia prevalence was higher in patients with versus without social frailty (20.6% vs. 11.8%, p = 0.04). Event rates for the composite outcome differed across groups (absence of social frailty and sarcopenia: 1.9% vs. presence of social frailty or sarcopenia: 3.0% vs. presence of both: 33.3%; log-rank p < 0.001). In the multivariable Cox model, no significant difference existed between absence of social frailty and sarcopenia and presence of social frailty or sarcopenia (hazard ratio 2.44; 95% confidence interval 0.51-11.52; p = 0.26), while presence of both had higher risk compared with absence of both (hazard ratio 12.98; 95% confidence interval 2.46-68.50; p < 0.01).CONCLUSION:The coexistence of social frailty and sarcopenia is associated with adverse outcomes in outpatients with stage B HF. Early identification and multidisciplinary interventions for social frailty may help improve long-term prognosis. |
| DOI | 10.1111/ggi.70597 |
| PMID | 42297732 |