論文種別	症例報告
言語種別	英語
査読の有無	その他(不明)
表題	Solid Pseudopapillary Neoplasm of the Pancreas Showing Spontaneous Regression Followed by Regrowth: A Case Report.
掲載誌名	正式名：Surgical case reports 略　 称：Surg Case Rep ISSNコード：21987793/21987793
掲載区分	国外
巻・号・頁	12(1),pp.26-0188
著者・共著者	Yuji Ikeda, Daisuke Hashimoto, So Yamaki, Kazuki Matsumura, Hiroyuki Ishida, Satoshi Mii, Hidetaka Miyazaki, Yuki Matsui, Sang Thanh Nguyen, Sohei Satoi
発行年月	2026
概要	INTRODUCTION:Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant tumor. Although SPNs generally exhibit indolent behavior, spontaneous regression detected on CT imaging is exceedingly rare, and to the best of our knowledge, regrowth following regression has not been previously reported.CASE PRESENTATION:A 33-year-old woman was referred to Kansai Medical University following the detection of liver dysfunction during a routine medical checkup. Imaging revealed a well-demarcated 20-mm mass in the pancreatic body, and an endoscopic US-guided biopsy confirmed SPN. Surgical resection was initially planned but postponed because of a COVID-19 infection in a fellow inpatient. During follow-up, the tumor showed spontaneous regression and became undetectable on imaging at 4 months. However, MRI at 16 months revealed tumor regrowth, which became clearly visible on T2-weighted imaging by 23 months, measuring 15 mm. At 24 months, a laparoscopic spleen-preserving distal pancreatectomy was performed. Histopathology confirmed SPN with intratumoral hemorrhage and characteristic pseudopapillary architecture. Complete resection was achieved, and the patient's postoperative course was uneventful.CONCLUSIONS:This case illustrates that SPN can regress spontaneously, yet subsequently regrow, underscoring the need for careful long-term imaging surveillance even after apparent tumor shrinkage.
DOI	10.70352/scrj.cr.26-0188
PMID	42292024