論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Structural insights into spectral tuning and retinal exchange in cone visual pigments.
掲載誌名	正式名：Science (New York, N.Y.) 略　 称：Science ISSNコード：10959203/00368075
掲載区分	国外
巻・号・頁	392(6805),pp.eadz3996
著者・共著者	Sayaka Ohashi, Kota Katayama, Asato Kojima, Xuchun Yang, Masahiro Fukuda, Filippo Sacchetta, Ryoji Suno, Yukihiko Sugita, Nipawan Nuemket, Suhyang Kim, Kazuhiro Kobayashi, Hiroo Imai, So Iwata, Eriko Nango, Takuya Kobayashi, Takeshi Noda, Massimo Olivucci, Hideaki E Kato, Hideki Kandori
発行年月	2026/06
概要	Color vision in catarrhine primates relies on red-, green-, and blue-sensitive cone pigments that share an 11-cis-retinal chromophore but differ in absorption maxima. Red and green pigments arose by recent gene duplication and differ at only a few residues. Here, we report cryo-electron microscopy structures of red and green cone pigments from the cynomolgus macaque (Macaca fascicularis) integrated with low-temperature vibrational spectroscopy and quantum mechanical and molecular mechanical modeling. The red-green spectral shift is dominated by threonine 285, the hydroxyl dipole of which modulates chromophore electrostatics, whereas steric effects appear modest. We also identified membrane-facing lateral openings in cone pigments but not in inactive rhodopsin. Comparisons with active-state structures suggest activation-dependent gating, and mutational and spectroscopic analyses support a role for this opening in retinal uptake and rapid pigment regeneration.
DOI	10.1126/science.adz3996
PMID	42348681