論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY).
掲載誌名	正式名：Japanese journal of clinical oncology 略　 称：Jpn J Clin Oncol ISSNコード：14653621/03682811
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Kota Kawabata, Koichi Yasuda, Satoaki Nakamura, Yoshitaka Honma, Ryusuke Suzuki, Yuri Ueda, Satoshi Saito, Kazuto Matsuura, Nobuhiro Hanai, Naoki Nakamura, Junki Mizusawa, Keita Sasaki, Haruhiko Fukuda, Takashi Mizowaki, Naomi Kiyota,
発行年月	2026/06
概要	Chemoradiotherapy (CRT) with high-dose cisplatin (100 mg/m2) is the standard treatment for locally advanced squamous cell carcinoma of the head and neck (SCCHN). However, this regimen is often intolerable in elderly patients because of its toxicity, and the optimal treatment for those unfit for high-dose cisplatin remains unclear. CRT with weekly cisplatin (40 mg/m2) has been developed as a more tolerable alternative and has demonstrated comparable efficacy with reduced toxicity in several trials involving nonelderly patients. We therefore designed a multicenter, randomized phase III trial (JCOG2405) to confirm the superiority of CRT with weekly cisplatin over radiotherapy alone in patients aged ≥70 years with locally advanced SCCHN who are unfit for high-dose cisplatin. The primary endpoint is overall survival. A total of 250 patients from 59 institutions will be enrolled over 5 years. The trial has been registered in the Japan Registry of Clinical Trials (study number: jRCTs031250688).
DOI	10.1093/jjco/hyag097
PMID	42341154