| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan. |
| 掲載誌名 | 正式名：Journal of gastroenterology 略 称：J Gastroenterol ISSNコード：14355922/09441174 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online ahead of print |
| 著者・共著者 | Tetsuya Takikawa, Yoichi Kakuta, Kazuhiro Kikuta, Serina Haruyama, Ami Kawamoto, Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroshi Nagai, Takanori Sano, Mikihiro Fujiya, Takuto Saiki, Masanao Nakamura, Atsushi Nishida, Sakiko Hiraoka, Takayuki Matsumoto, Katsuya Endo, Kazuyuki Narimatsu, Shojiro Yamamoto, Takashi Kagaya, Shin-Ichiro Hagiwara, Noritaka Takatsu, Hiroshi Nakase, Kazuichi Okazaki, Yoki Furuta, Tetsu Kinjo, Soichiro Ishihara, Hirotake Sakuraba, Takashi Tashiro, Makoto Naganuma, Fukunori Kinjo, Tomohisa Takagi, Tadakazu Hisamatsu, Mitsuhiro Kawano, Atsushi Masamune, |
| 発行年月 | 2026/06 |
| 概要 | BACKGROUND:Patients with inflammatory bowel disease (IBD) are at increased risk of acute pancreatitis (AP). However, the clinical characteristics of AP in IBD and the differences between ulcerative colitis (UC) and Crohn's disease (CD) remain unclear.METHODS:We conducted a nationwide, multicenter, retrospective study at 28 institutions in Japan. Patients ≥ 16 years with UC or CD treated between 2012 and 2021 were included. We assessed the characteristics of AP in IBD, including differences between UC and CD. We also compared UC and CD patients with and without AP.RESULTS:Among 24,849 patients with IBD (16,233 UC and 8,616 CD), 342 (1.4%) developed AP. Among these AP cases, severe AP and mortality were observed in 7.6% and 0.6%, respectively. Drug-induced AP was the most common etiology (55.6%), and autoimmune pancreatitis (AIP) ranked third (10.8%). Compared with UC, CD patients with AP had higher rates of intensive care unit admission (P = 0.002) and severe AP (P = 0.003). CD (odds ratio, 2.96; P = 0.02) and drug-induced or AIP etiology (odds ratio, 0.19; P < 0.001) were associated with severe AP. UC patients with AP had higher rates of pancolitis (P < 0.001), extraintestinal manifestations (P = 0.001), and steroid dependence (P = 0.006) than those without AP.CONCLUSIONS:AP in IBD showed distinct clinical characteristics compared with AP in the general population. CD patients may develop more severe AP than UC, whereas UC patients with AP may have more aggressive and/or refractory disease features compared with those without AP. |
| DOI | 10.1007/s00535-026-02476-4 |
| PMID | 42371096 |