論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Impact of Stent Type on Surgical Outcomes in Pancreatic Cancer Patients Undergoing Preoperative Biliary Drainage.
掲載誌名	正式名：Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 略　 称：Dig Endosc ISSNコード：14431661/09155635
掲載区分	国外
巻・号・頁	38(7),pp.e70229
著者・共著者	Takashi Tamura, Tomoaki Matsumori, Yoshihiro Nishikawa, Koh Kitagawa, Minako Nagai, Atsushi Shimizu, Ippei Matsumoto, Atsuhiro Masuda, Arata Sakai, Takuo Yamai, Akira Tomokuni, Tsukasa Ikeura, Takashi Ito, Toshifumi Doi, Hayato Miyake, Hirotsugu Maruyama, Yuki Ishikawa-Kakiya, Takeshi Ogura, Saori Ueno, Hideyuki Shiomi, Akiko Tsujimoto, Shuhei Shintani, Tetsuya Ikeda, Yoshito Uenoyama, Tomoya Emori, Masaaki Shimatani, Keisuke Hanada, Masayuki Kitano, Mamoru Takenaka
発行年月	2026/07
概要	BACKGROUND AND AIM:Metal (MS) or plastic stents (PS) are placed for preoperative biliary drainage (PBD) in patients with pancreatic ductal adenocarcinoma (PDAC) undergoing neoadjuvant chemotherapy (NAC) or chemoradiotherapy (NACRT). This multicentre retrospective study compared the safety and efficacy of PBD using MS and PS, including surgery-related adverse events (AEs) and other clinical outcomes.METHODS:This study enrolled patients with resectable or borderline resectable PDAC requiring NAC or NACRT who underwent PBD with MS or PS at 17 tertiary care hospitals in Japan between January 2016 and December 2021. Clinical outcomes were retrospectively analysed.RESULTS:Of the 249 patients who underwent pancreatectomy, 121 underwent PBD with MS and 128 with PS. Because there were significant differences in baseline characteristics between these groups, propensity score matching was performed, resulting in 66 matched pairs. The RBO rate was significantly lower (15.2% vs. 56.1%, p < 0.001); the time to surgery (p = 0.027) and postoperative hospital stay (p = 0.036) were significantly shorter in the MS group. The incidence of postoperative AEs was significantly lower in the MS group (18.2% vs. 34.9%, p = 0.030) than in the PS group. Univariate and multivariate analyses identified the placement of an MS for PBD as an independent protective factor for postoperative AEs (odds rates: 0.35, p = 0.017).CONCLUSION:In patients with PDAC undergoing NAC or NACRT, MS placement for PBD was associated with lower rates of postoperative AEs and RBO than PS placement. MS is a more suitable option than PS for PBD.
DOI	10.1111/den.70229
PMID	42433174