論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Medial Meniscus Extrusion During Weight-Bearing in Early-Stage Knee Osteoarthritis.
掲載誌名	正式名：Annals of biomedical engineering 略　 称：Ann Biomed Eng ISSNコード：15739686/00906964
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	Masahide Yagi, Masashi Taniguchi, Kenta Iwane, Shogo Okada, Sayaka Okada, Yoshiki Motomura, Yoshihiro Fukumoto, Masashi Kobayashi, Kyoseki Kanemitsu, Noriaki Ichihashi
発行年月	2026/07
概要	PURPOSE:To determine whether medial meniscus extrusion (MME) measured in the standing or supine position better characterizes early-stage knee osteoarthritis (OA) and to assess the association between MME in the optimal position and physical function.METHODS:This study included 43 community-dwelling women. MME was measured beneath the medial collateral ligament in the supine and standing positions. Early OA was defined by a Kellgren-Lawrence grade of 0-1, tenderness and/or stiffness around the knee, and a knee society score (KSS) symptom subscore ≤ 22. Thirteen participants were classified as having early OA, and 30 as asymptomatic. Firth logistic regression analysis was used to determine which MME measurement was more strongly associated with early OA. Multiple linear regression analysis was conducted to explore associations between the KSS function subscore and the MME in the predictive position.RESULTS:MME standing was significantly greater in the early OA group than in the asymptomatic group (4.5 ± 1.2 mm vs. 3.1 ± 0.9 mm; p < 0.001; d = 1.3) and was independently associated with early knee OA (OR = 18.13 per 1 mm increase, 95%CI 1.88-323.91, p = 0.011). In regression models, MME standing was associated with self-reported knee function (β = - 0.31, p = 0.034), independently of quadriceps strength (β = 0.38, p = 0.004).CONCLUSION:MME measured under weight-bearing conditions can help differentiate individuals with early knee OA from asymptomatic individuals with similar radiographic features and is associated with self-reported knee function, suggesting its potential as an adjunctive clinical indicator.
DOI	10.1007/s10439-026-04271-x
PMID	42463568