論文種別	症例報告
言語種別	日本語
査読の有無	その他(不明)
表題	臀部に生じた低悪性度線維粘液性肉腫の1例
掲載誌名	正式名：皮膚の科学 ISSNコード：13471813
出版社	日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会
巻・号・頁	25(1),28-34
著者・共著者	植村 彩記, 金 晴惠, 岡本 千明, 浦上 貴弘, 小林 里佳, 津田 真里, 四十万谷 貴子, 寺井 沙也加, 槇村 馨, 清原 隆宏
発行年月	2026/03
概要	<p>A 71-year-old male presented with a 12 cm subcutaneous mass in the left gluteal region that was freely mobile beneath the overlying skin. MRI showed a heterogeneous high signal on T2-weighted and diffusion-weighted imaging, raising suspicion of a soft tissue sarcoma. Hematoxylin and eosin staining revealed a mixture of heavily fibrotic and myxoid-rich areas with an abrupt transition. In the fibrous regions, there was proliferation of atypical spindle cells with mild cytologic atypia, whereas the myxoid areas demonstrated hyalinization and rosette-like structures. In addition, areas of vascular proliferation were noted. MUC4 was diffusely positive in the cytoplasm of the suspected tumor cells and Ki-67-positive cells were sparse. Based on these findings, a diagnosis of low-grade fibromyxoid sarcoma (LGFMS) was made. Twelve months after wide excision, there has been no evidence of metastasis or recurrence. LGFMS, also known as Evans tumor, is classified under fibroblastic/myofibroblastic tumors, malignant, in the 5th edition of the WHO Classification of Tumours of Soft Tissue and Bone. Although it exhibits low cellular atypia, its long-term prognosis is considered poor due to the potential for recurrence and metastasis, necessitating careful monitoring. Herein, we report a relatively rare case of LGFMS definitively diagnosed by MUC4 immunohistochemistry, with a review of the literature. Skin Research, 25 : 28-34, 2026</p>
DOI	10.11340/skinresearch.25.1_28
NAID	1390308685092627200