| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Cognitive function predicts all-cause mortality independent of social engagement among community-dwelling elderly Japanese men: a 15-year prospective cohort study. |
| 掲載誌名 | 正式名：Environmental health and preventive medicine 略 称：Environ Health Prev Med ISSNコード：13474715/1342078X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 31,pp.56 |
| 著者・共著者 | Yuki Fujita, Masayuki Morikawa, Katsuyasu Kouda, Junko Tamaki, Nozomi Okamoto, Masayuki Iki |
| 発行年月 | 2026 |
| 概要 | BACKGROUND:As the global population ages, cognitive impairment has become a growing public health concern. Although epidemiological studies have examined its association with mortality, sex-stratified analyses and community-based investigations in elderly Asian men remain scarce. Furthermore, social engagement may confound the association between cognitive impairment and mortality; yet few studies among community-dwelling elderly Asian men have simultaneously examined cognitive impairment and social engagement in relation to all-cause mortality in a prospective cohort design. This study therefore aimed to examine whether cognitive impairment is associated with an increased risk of all-cause mortality independent of social engagement among community-dwelling elderly Japanese men over a 15-year follow-up period.METHODS:This prospective cohort study enrolled 2,174 men aged ≥65 years. Follow-up assessments were conducted at five, ten, and fifteen years, with all-cause mortality as the primary outcome. Cognitive function was assessed using the Mini-Mental State Examination. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models to examine the association between cognitive function and all-cause mortality. Confounder-adjusted Kaplan-Meier survival curves were generated using inverse probability of treatment weighting.RESULTS:The final analytic sample comprised 1,741 men. High social engagement was associated with a lower risk of all-cause mortality. Compared with participants with normal cognitive function, the hazard ratios (HRs) for all-cause mortality were 1.29 (95% CI: 1.06-1.56) for mild cognitive impairment and 1.59 (95% CI: 1.10-2.29) for severe cognitive impairment, after adjusting for potential confounding factors including social engagement.CONCLUSIONS:Cognitive impairment independently predicts an increased risk of all-cause mortality in community-dwelling elderly Japanese men. |
| DOI | 10.1265/ehpm.26-00105 |
| PMID | 42649026 |